八木 洋


内視鏡手術トレーニングセンター
ディレクター



AMED再生NW 研究代表



AMDAP採択事業MatriSurge代表



AMED先端計測・機器開発研究代表


専任講師
八木 洋(やぎ ひろし)
1998年 慶應義塾大学医学部卒
     日本消化器外科学会指導医
     日本外科学会指導医
     日本移植学会認定医・代議員
     日本内視鏡外科学会技術認定医

専門領域
肝胆膵外科、移植外科、再生医療研究
コメント
肝胆膵に関わる病気全般に幅広く丁寧に対応いたします。また早くiPS細胞治療が患者様の元に届くよう、臓器再生特に肝臓の再生医療の実現化に鋭意取り組んでおります。再生医療の現状などについてもご相談をお受けいたします。

経歴

1998年慶應義塾大学医学部外科 研修医
1999年芳賀赤十字病院外科 研修医
2000年国家公務員共済組合連合会立川病院外科 専修医
2001年慶應義塾大学医学部外科学教室(一般・消化器)レジデント
2003年京都大学移植外科 医員
2003年慶應義塾大学医学部外科学教室(一般・消化器)チーフレジデント
2004年日野市立病院外科 医員
2007年米国Massachusetts General Hospital 研究員
2010年慶應義塾大学医学部外科学(一般・消化器)助教
2015年慶應義塾大学医学部外科学(一般・消化器)専任講師(学部内)
2018年慶應義塾大学医学部外科学(一般・消化器)専任講師

資格


所属学会


受賞歴

2015年AASLD(米国肝臓病学会)Presidential Poster of Distinction Award
2013年日本消化器外科学会賞(JSGS Young Investigator of the Year 2013)
2012年抗加齢学会研究奨励賞
2011年慶應義塾大学医学部三四会奨励賞
2011年日本再生医療学会ベストポスター賞
2010年The 1st JSGE International Topic Conference Best Poster Award
2008年AASLD(米国肝臓病学会)Young Investigator Travel Award

学位指導者受賞歴

2018年第43回日本心臓財団研究奨励(稲葉佑)
2017年ISS/SIC Lloyd M. Nyhus Prize(東尚伸)
2016年第42回日本心臓財団研究奨励賞(河西未央)
2015年The 29th EACTS annual meeting Young investigator award(北原大翔)
2014年9th Annual Academic Surgical Congress Best Abstract award(菊池弘人)
2012年日本創傷治癒学会 第42回研究奨励賞(門多由恵)

助成金

2019~22年度AMED医療分野研究成果展開事業(先端計測分析技術・機器開発プログラム)
2018~20年度AMED再生医療実現拠点ネットワークプログラム 技術開発個別課題
2018年文部科学省科学研究費 挑戦的研究(萌芽)
2018年文部科学省科学研究費 基盤B
2018年武田薬品工業株式会社 COCKPI-T®
2018年第一三共株式会社 TaNeDS
2017年武田科学振興財団 医学系研究奨励
2016年文部科学省 橋渡し研究加速ネットワークプログラム シーズA
2015年ものづくり・商業・サービス革新補助金(研究分担者)
2013~18年AMED再生医療実現拠点ネットワークプログラム 技術開発個別課題(研究推進主任)
2012年佐川がん研究振興財団 がん研究助成
2011~13年文部科学省科学研究費 若手A
2011年かなえ医薬振興財団研究助成
2010~12年慶應義塾大学次世代研究プロジェクト推進プログラム
2010~12年JST日本-イスラエル戦略的共同研究推進事業(研究分担者)
2010年武田科学振興財団研究助成
2010年持田記念医学薬学振興財団研究助成
2010年公益信託外科学研究助成

再生医療研究詳細


論文

1.Watanabe M, Yano K, Okawa K, Yamashita T, Tajima K, Sawada K, Yagi H, Kitagawa Y, Tanishita K, Sudo R. Construction of sinusoid-scale microvessels in perfusion culture of a decellularized liver. Acta Biomaterialia 95, 307-318, 2019.
2.Shimoda H, Yagi H, Higashi H, Tajima K, Kuroda K, Abe Y, Kitago M, Shinoda M, Kitagawa Y. Decellularized liver scaffolds promote liver regeneration after partial hepatectomy. Scientific Reports 9(1):12543, 2019
3.Inaba Y, Yagi H, Kuroda K, Kato J, Kawai Y, Kasai M, Kitahara H, Ito T, Osako M, Kitagawa Y, Shimizu H. Transplantation of a decellularized mitral valve complex in pigs. Surgery Today. Epub ahead of print, 2019.
4.Wakabayashi T, Yagi H, Tajima K, Kuroda K, Shinoda M, Kitago M, Abe Y, Oshima G, Hirukawa K, Itano O, Kitagawa Y. Efficacy of New Polylactic Acid Nonwoven Fabric as a Hemostatic Agent in a Rat Liver Resection Model. Surg Innov. 2019 In print
5.Inomata K, Tajima K, Yagi H, Higashi H, Shimoda H, Matsubara K, Hibi T, Abe Y, Tsujikawa H, Kitago M, Shinoda M, Obara H, Itano O, Soto-Gutierrez A, Kitagawa Y. A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus. Scientific Reports, 2018, In print
6.Tajima K, Yagi H, Kitagawa Y. Human-scale liver harvest and decellularization for pre-clinical research. Springer Protocols, Methods in Molecular Biology, 2017, In print.
7.Takagi C, Yagi H, Hieda M, Tajima K, Hibi T, Abe Y, Kitago M, Shinoda M, Itano O, Kitagawa Y. Mesenchymal stem cells contribute to hepatic maturation of human induced pluripotent stem cells. European Surgical Research, 58(1-2): 27-39, 2016.
8.Katsuki Y, Yagi H, Okitsu T, Kitago M, Tajima K, Kadota Y, Hibi T, Abe Y, Shinoda M, Itano O, Takeuchi S, Kitagawa Y. Endocrine pancreas engineered using porcine islets and partial pancreatic scaffolds. Pancreatology, 16(5): 922-930, 2016.
9.Kishida N, Matsuda S, Itano O, Shinoda M, Kitago M, Yagi H, Abe Y, Hibi T, Masugi Y, Aiura K, Sakamoto M, Kitagawa Y. Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. BMC Gastroenterology 16(1): 61, 2016.
10.Kitahara H, Yagi H, Tajima K, Okamoto K, Yoshitake A, Aeba R, Kudo M, Kashima I, Kawaguchi S, Hirano A, Kasai M, Akamatsu Y, Oka H, Kitagawa Y, Shimizu H. Heterotopic transplantation of a decellularized and recellularized whole porcine heart. Interactive cardiovascular and thoracic surgery 22(5): 571-579, 2016.
11.Collin de l'Hortet A, Takeishi K, Guzman-Lepe J, Handa K, Matsubara K, Fukumitsu K, Dorko K, Presnell SC, Yagi H, Soto-Gutierrez A. Liver-Regenerative Transplantation: Regrow and Reset. American Journal of Transplantation 16(6): 1688-1696, 2016.
12.Matsubara K, Yokota S, Ono Y, Fukumitsu K, Handa K, Guzman-Lepe J, Perez-Gutierrez A R, Yagi H, Fox I J, Murase N, Soto-Gutierrez A. Surgical Model of Auxiliary Partial Liver Transplantation in the Rat. Protocol Exchange, 2015.
13.Ei S, Hibi T, Tanabe M, Itano O, Shinoda M, Kitago M, Abe Y, Yagi H, Okabayashi K, Sugiyama D, Wakabayashi G, Kitagawa Y. Cryoablation Provides Superior Local Control of Primary Hepatocellular Carcinomas of >2 cm Compared with Radiofrequency Ablation and Microwave Coagulation Therapy: An Underestimated Tool in the Toolbox. Ann Surg Oncol 22(4): 1294-1300, 2015.
14.Tanaka M, Shinoda M, Takayanagi A, Oshima G, Nishiyama R, Fukuda K, Yagi H, Hayashida T, Masugi Y, Suda K, Yamada S, Miyasho T, Hibi T, Abe Y, Kitago M, Obara H, Itano O, Takeuchi H, Sakamoto M, Tanabe M, Maruyama I, Kitagawa Y. Gene transfer of high-mobility group box 1 box-A domain in a rat acute liver failure model. J Surg Res 194(2): 571-580, 2015.
15.Shinoda M, Kishida N, Itano O, Ei S, Ueno A, Kitago M, Abe Y, Hibi T, Yagi H, Masugi Y, Tanabe M, Aiura K, Sakamaoto M, Tanimoto A, Kitagawa Y. Long-term complete response of advanced hepatocellular carcinoma treated with multidisciplinary therapy including reduced dose of sorafenib: case report and review of the literature. World J Surg Oncol 13(144), 2015.
16.Tanaka M, Kitago M, Akiyama N, Iwamaru A, Yamamoto T, Suzuki F, Hibi T, Abe Y, Yagi H, Shinoda M, Itano O, Ogata K, Kitagawa Y. Usefulness of immunohistochemical studies in diagnosing metachronous gallbladder and small intestinal metastases from lung cancer with gastrointestinal hemorrhage: a case report. World J Surg Oncol 13: 63, 2015.
17.Mishima K, Obara H, Sugita K, Shinoda M, Kitago M, Abe Y, Hibi T, Yagi H, Matsubara K, Mori T, Fujimura H, Itano O, Hasegawa N, Iwata S, Kitagawa Y. Helicobacter cinaedi bacteremia with cellulitis after ABO-incompatible living-donor liver transplantation: Case report. World J Gastroenterol 21(55): 7911-7915, 2015.
18.Ei S, Shinoda M, Itano O, Obara H, Kitago M, Hibi T, Yagi H, Abe Y, Matsubara K, Ono Y, Kawachi S, Hoshino K, Kuroda T, Tanabe M, Kitagawa Y. Effects of Addition of Early Enteral Nutritional Support During the Postoperative Phase in Patients After Living-donor Liver Transplantation. Ann Transplant 20(357): 365, 2015.
19.Kishida N, Hibi T, Itano O, Okabayashi K, Shinoda M, Kitago M, Abe Y, Yagi H, Kitagawa Y. Validation of Hepatectomy for Elderly Patients with Hepatocellular Carcinoma. Ann Surg Oncol 22(9): 3094-3101, 2015.
20.Itano O, Oshima G, Kitago M, Suzuki K, Hayatsu S, Shinoda M, Abe Y, Hibi T, Yagi H, Ikoma N, Aiko S, Kitagawa Y.. Harness Traction Technique (HARNESS): Novel Method for Controlling the Transection Plane During Laparoscopic Hepatectomy. Surg Laparosc Endosc Percutan Tech 25(4): e117-e121, 2015.
21.Itano O, Oshima G, Minagawa T, Shinoda M, Kitago M, Abe Y, Hibi T, Yagi H, Ikoma N, Aiko S, Kawaida M, Masugi Y, Kameyama K, Sakamoto M, Kitagawa Y. Novel strategy for laparoscopic treatment of pT2 gallbladder carcinoma. Surg Endosc 29(12): 3600-3607, 2015.
22.Kishida N, Shinoda M, Masugi Y, Itano O, Fujii-Nishimura Y, Ueno A, Kitago M, Hibi T, Abe Y, Yagi H, Tanimoto A, Tanabe M, Sakamaoto M, Kitagawa Y. Cystic tumor of the liver without ovarian-like stroma or bile duct communication: two case reports and a review of the literature. World J Surg Oncol, 12: 229, 2014.
23.Kikuchi H, Yagi H, Hasegawa H, Ishii Y, Okabayashi K, Tsuruta M, Hoshino G, Takayanagi A, Kitagawa Y. Therapeutic potential of transgenic mesenchymal stem cells engineered to mediate anti-high mobility group box 1 activity: targeting of colon cancer. Journal of Surgical Research, 190(1): 134-143, 2014.
24.Shinoda M, Tanabe M, Itano O, Obara H, Kitago M, Abe Y, Hibi T, Yagi H, Fujino A, Kawachi S, Hoshino K, Kuroda T, Kitagawa Y. Left-side hepatectomy in living donors: through a reduced upper-midline incision for liver transplantation. Transplantation Proceedings, 46(5): 1400-1406, 2014.
25.Kadota Y, Yagi H, Inomata K, Matsubara K, Hibi T, Abe Y, Kitago M, Shinoda M, Obara H, Itano O, Kitagawa Y. Mesenchymal stem cells support hepatocyte function in engineered liver grafts. Organogenesis, 10(2): 268-277, 2014.
26.Yagi H. Special issue "organ replacement approaches". Organogenesis, 10(2): 194-195, 2014.
27.Abe Y, Itano O, Kitago M, Shinoda M, Yagi H, Hibi T, Takano K, Chiba N, Kawachi S, Shimazu M, Kitagawa Y. Computer assisted surgery, preoperative planning and navigation for pancreatic cancer. J Hepatobiliary Pancreat Sci, 21(4): 251-255, 2014.
28.Nishiyama R, Shinoda M, Tanabe M, Oshima G, Takano K, Miyasho T, Fuchimoto Y, Yamada S, Inoue T, Shimada K, Suda K, Tanaka M, Hayashida T, Yagi H, Kitago M, Obara H, Itano O, Takeuchi H, Kawachi S, Maruyama I, Kitagawa Y. Hemoadsorption of high-mobility group box chromosomal protein 1 using a column for large animals. Eur Surg Res, 51(3-4): 181-190, 2014.
29.Shinoda M, Tanabe M, Itano O, Obara H, Kitago M, Abe Y, Hibi T, Yagi H, Fujino A, Kawachi S, Hoshino K, Kuroda T, Kitagawa Y. Left-side hepatectomy in living donors: through a reduced upper-midline incisionfor liver transplantation. Transplantation Proceedings 46(5): 1400-1406, 2014.
30.Yagi H, Kitagawa Y. The role of mesenchymal stem cells in cancer development. Front Genet. 2013;27(4):261
31.Yagi H, Soto-Gutierrez A, Kitagawa Y. Whole-organ re-engineering: a regenerative medicine approach in digestive surgery for organ replacement. Surg Today. 2013;43(6):587-94
32.Yagi H, Fukumitsu K, Fukuda K, et al. Human-Scale Whole-Organ Bioengineering for Liver Transplantation: a Regenerative Medicine Approach. Cell Transplant 2013;22(2):231-42
33.Yagi H, Soto-Gutierrez A, Kitagawa Y. Decellularized scaffold as a platform for novel regenerative therapy. Nihon Geka Gakkai Zasshi. 2012 Sep;113(5):419-23. Japanese.
34.Fukuda K, Saikawa Y, Yagi H, Wada N, Takahashi T, Kitagawa Y. Role of integrin α1 subunits in gastric cancer patients with peritoneal dissemination. Mol Med Report. 2011 Oct 21.
35.Fukumitsu K, Yagi H, Soto-Gutierrez A. Bioengineering in organ transplantation: targeting the liver. Transplant Proc. 2011 Jul-Aug;43(6):2137-8.
36.Shulman M, Cohen M, Soto-Gutierrez A, Yagi H, Wang H, Goldwasser J, Lee-Parsons CW, Benny-Ratsaby O, Yarmush ML, Nahmias Y. Enhancement of naringenin bioavailability by complexation with hydroxypropoyl-β-cyclodextrin. PLoS One. 2011 Apr 6;6(4):e18033
37.Koria P, Yagi H, Kitagawa Y, Megeed Z, Nahmias Y, Sheridan R, Yarmush ML. Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds. Proc Natl Acad Sci USA. 2011 Jan 18;108(3):1034-9
38.Matsuura Y, Yagi H, Matsuda S, Itano O, Aiura K, Kuroda S, Ueda M, Kitagawa Y. Human liver-specific nanocarrier in a novel mouse xenograft model bearing noncancerous human liver tissue. Eur Surg Res. 2010 Dec 20;46(2):65-72
39.Uygun BE, Soto-Gutierrez A, Yagi H, Izamis ML, Shulman CJ, Milwid J, Nahmias Y, Tilles A, Berthiaume F, Hertl M, Yarmush ML, Uygun K. Using decellularized liver as a scaffold to remake a new organ graft for transplantation. Nature Medicine. 2010 Jul;16(7):814-20
40.Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, Tilles AW, Tompkins RG, Parekkadan B, Yarmush ML. Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1. Mol Ther. 2010 Oct;18(10):1857-64
41.Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML. Mesenchymal Stem Cell: Mechanisms of Immunomodulation and Homing. Cell Transpl. 2010;19(6):667-79
42.Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML. Bone Marrow Mesenchymal Stromal Cells Attenuate Organ Injury Induced by LPS and Burn. Cell Transpl. 2010;19(6):823-30
43.Soto-Gutierrez A*, Yagi H*, Uygun BE, Navarro-Alvarez N, Uygun K, Kobayashi N, Yang YG, Yarmush ML. Cell Delivery: From Cell Transplantation to Organ Engineering. Cell Transpl. 2010;19(6):655-65
44.Soto-Gutierrez A, Navarro-Alvarez N, Yagi H, Nahmias Y, Yarmush ML, Kobayashi N. Engineering of an Hepatic Organoide to Develop Liver Assist Devices. Cell Transpl. 2010;19(6):815-22
45.Uygun K, Tolboom H, Izamis ML,Sharma N, Milwid JM, Yagi H, Kobayashi N, Yarmush ML, Hertl M. Diluted Blood Reperfusion as a Model for Transplantation of Ischemic Rat Livers: ALT is a Direct Indicator of Viability. Transplant Proc. 2010 Sep;42(7):2463-7
46.van Poll D, Nahmias Y, Soto-Gutierrez A, Ghasemi M, Yagi H, Kobayashi N, Yarmush ML, Hertl M. Human immune reactivity against liver sinusoidal endothelial cells from GalTα(1,3)GalT-deficient pigs. Cell Transplant. 2010;19(6):783-9.
47.Yagi H, Tafaleng E, Nagaya M, Strom SC, Fox IJ, Soto-Gutierrez A. Embryonic and Induced Pluripotent Stem Cells as a Model for Liver Disease. Crit Rev Bioeng. 37(4-5):377-98:2009
48.Yagi H, Parekkadan B, Suganuma K, Soto-Gutierrez A, Tompkins RG, Tilles A, Yarmush ML. Long Term Superior Performance of a Stem Cell/Hepatocyte Device for the Treatment of Acute Liver Failure. Tissue Eng Part A. 15(11):3377-88:2009
49.Soto-Gutierrez A*, Navarro-Alvarez N*, Yagi H*, Yarmush ML. Stem cells for liver repopulation. Curr Opin Organ Transplant. 14(6):667-73:2009
50.Yagi H, Ueda M, Jinno H, Aiura K, Mikami S, Tada H, Seno M, Yamada H, Kitajima M. Anti-tumor effect in an in vivo model by human-derived pancreatic RNase with basic fibroblast growth factor insertional fusion protein through antiangiogenic properties. Cancer Sci. 2006 Dec; 97(12):1315-20.
51.Yagi H, Shimazu M, Kawachi S, Tanabe M, Aiura K, Wakabayashi G, Ueda M, Nakamura Y, Kitajima M. Retrospective analysis of outcome in 63 gallbladder carcinoma patients after radical resection. J Hepatobiliary Pancreat Surg. 2006; 13(6):530-6
52.Yagi H, Takada Y, Fujimoto Y, Ogura Y, Kozaki K, Ueda M, Tanaka K. Successful surgical ligation under intraoperative portal vein pressure monitoring of a large portosystemic shunt presenting as an intrapulmonary shunt: report of a case. Surg Today. 2004;34(12):1049-52.
53.Yagi H, Ueda M, Kawachi S, Tanabe M, Aiura K, Wakabayashi G, Shimazu M, Sakamoto M, Kitajima M. Squamous cell carcinoma of the liver originating from non-parasitic cysts after a 15 year follow-up. Eur J Gastroenterol Hepatol. 2004 Oct;16(10):1051-6.

著書

1. 脱・再細胞化肝臓の大動物モデルを用いた有効性試験の現状
八木洋
株式会社シーエムシー出版, 脱細胞化組織の作製法と医療・バイオ応用:140-148, 2019
2. 誌上ディベート 第12回 早期胆嚢癌疑診例のラパコレ;Yes vs. No|Yesの立場から
慶應義塾大学医学部外科学(一般・消化器)/八木 洋 他
へるす出版「消化器外科」2019年第42巻第3号
3. 脱細胞化組織を利用した肝組織再構築-臨床応用に向けて-
八木洋・北川雄光
「バイオマテリアル-生体材料-」
特 集:再生医療用バイオマテリアルとしての細胞外マトリックス 36-2, 2018
4. 実質臓器再生の実現化に向けて : 細胞外骨格の利用
八木洋, 篠田昌宏, 北川雄光
医学のあゆみ. 262(4),317-322,2017
5. 脱細胞化臓器骨格を用いた臓器再生医療
八木洋, 田島一樹, 日比泰造, 阿部雄太, 北郷実, 篠田昌宏, 板野理, 北川雄光
最新医学71(7):163-168, 2017
6. 幹細胞パッケージングを用いた臓器再生技術の開発
八木洋, 北川雄光
化学工業68(7):40-46, 2017
7. 診療科各科と再生医療の最前線 消化器疾患と再生医療
八木洋, 日比泰造, 阿部雄太, 北郷実, 篠田昌宏, 板野理, 北川雄光
先進医療NAVIGATOR 今日の再生医療, p.32-36,2016
8. 人工臓器と再生医療の融合 iPS細胞の新たな足場―脱細胞化肝臓骨格―
八木洋, 日比泰造, 阿部雄太, 北郷実, 篠田昌宏, 板野理, 北川雄光
人工臓器 45(1): 67-70,2016
9. 脱細胞化臓器骨格を用いた臓器再生医療
八木洋, 田島一樹, 日比泰造, 阿部雄太, 北郷実, 篠田昌宏, 板野理, 北川雄光
最新医学 71(7): 163-168, 2016
10. 過小グラフトとドナー年齢:基礎研究を踏まえた新たな治療モダリティの検討
門多由恵、八木洋、北川雄光他
日本門脈圧亢進症学会雑誌 20(1): 19-23 2014
11. 脱細胞化臓器骨格
八木洋、北川雄光
消化器外科「移植・再生医学最前線」37(8): 1315-1320 2014
12. 細胞マトリクスを用いた臓器・組織構築―細胞外マトリクスを用いた肝再生
八木洋、田邉稔、北川雄光
今日の移植 26(4):333-341 2013
13. Yagi H, Soto-Gutierrez A, Kitagawa Y, Yarmush ML.
Mesenchymal Stem Cell Therapy: Immunomodulation and Homing Mechanisms
Stem Cells and Cancer Stem Cells Volume 8, 2012, pp 91-104
14. 細胞外マトリックス(ECM)
八木洋, 北川雄光
G.I.Research 20(3): 252 -253 2012
15. 脱細胞化(decellularization)
八木洋, 北川雄光
G.I.Research 20(3): 254 -256 2012
16. 第6回 脱細胞化肝骨格を用いた肝臓再生
八木洋, 北川雄光
G.I.Research 20(2): 152 -157 2012
17. 第69回 バイオエンジニアリングとの出会い
八木洋
G.I.Research 19(4): 372 -375 2011

特許

US20130323708 A1 / WO2011002926A2 12/5/2013
Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same


ページトップへ